Total Synthesis of Natural Products
Multi-step routes to complex natural products and the methodology they motivate.
Total Synthesis of Natural Products — Multi-step routes to complex natural products and the methodology they motivate.
The field organises around several methodological axes: how the underlying objects are modelled, how they are measured, how they are connected to the rest of chemistry, and which empirical phenomena drive open questions. The references below anchor the topic in established treatments and current literature.
Foundations and core methods
A primary reference for this area is Classics in Total Synthesis (Nicolaou and Sorensen, 1996), which lays out the core concepts that govern total synthesis of natural products. The treatment frames the subject within the broader context of synthesis and motivates the conceptual vocabulary used throughout this page. The discussion here cites this work as a general anchor rather than for a specific claim, since the exact contribution claim is treated cautiously in line with the Charted sourcing policy.
Open questions
Open methodological questions in total synthesis of natural products include the transferability of the standard methods to harder regimes, the integration of newer measurement and modelling tools, and the connection to neighbouring subfields of synthesis. Future revisions of this page will deepen the treatment as more primary literature is curated.
Prerequisites
Sources
- textbook · primary · 1996Classics in Total Synthesisnicolaou-1996, sorensen-1996
In context
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