Click Chemistry
Modular, high-yield ligations — CuAAC, SPAAC, thiol-ene, and SuFEx.
Click Chemistry — Modular, high-yield ligations — CuAAC, SPAAC, thiol-ene, and SuFEx.
The field organises around several methodological axes: how the underlying objects are modelled, how they are measured, how they are connected to the rest of chemistry, and which empirical phenomena drive open questions. The references below anchor the topic in established treatments and current literature.
Foundations and core methods
Current developments
Further reading and adjacent contributions include Click Chemistry: Diverse Chemical Function from a Few Good Reactions (Kolb et al., 2001); Organic Chemistry (Clayden et al., 2012). Each of these is referenced as supporting background — they connect the topic to neighbouring methods, datasets, or open problems without our making specific claims about their individual findings beyond what is broadly accepted in the area.
Open questions
Open methodological questions in click chemistry include the transferability of the standard methods to harder regimes, the integration of newer measurement and modelling tools, and the connection to neighbouring subfields of synthesis. Future revisions of this page will deepen the treatment as more primary literature is curated.
Prerequisites
Sources
- paper · historical · 2001Click Chemistry: Diverse Chemical Function from a Few Good Reactionskolb-2001, finn-2001, sharpless-2001
- textbook · supporting · 2012Organic Chemistryclayden-2012, greeves-2012, warren-2012, wothers-2012
In context
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